What is Entresto?

• Entresto contains a combination of sacubitril and valsartan. Sacubitril is a blood pressure medicine. It works by increasing the levels of certain proteins in the body that can dilate (widen) blood vessels. This helps lower blood pressure by reducing sodium levels.
• Valsartan is an angiotensin II receptor blocker (sometimes called an ARB). Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.
• Entresto is used in certain people with chronic heart failure. This medicine helps lower the risk of needing to be hospitalized when symptoms get worse, and helps lower the risk of death from heart failure.
• Entresto is also used to treat heart failure in children who are at least 1 year old.
• Entresto is usually given together with other heart medications.

Important information

Do not use Entresto if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Entresto can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

If you have diabetes, do not use Entresto together with any medication that contains aliskiren.

Before taking this medicine

You should not use Entresto if you are allergic to sacubitril or valsartan (Diovan), or if you have ever had a severe allergic reaction to a blood pressure medication such as:

• an ACE inhibitor - captopril, enalapril, lisinopril, perindopril, ramipril or
• an ARB - azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan (Atacand, Diovan, Edarbi, Micardis, Teveten, and others).

You should not take Entresto within 36 hours before or after you have taken any ACE inhibitor medication.

You may also need to avoid taking Entresto with aliskiren if you have kidney disease.

To make sure Entresto is safe for you, tell your doctor if you have ever had:

• liver disease;
• diabetes;
• hereditary angioedema;
• if you are on a low-salt-diet; or
• if you are dehydrated.

Do not use Entresto if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Entresto can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.

It is not known whether sacubitril and valsartan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using Entresto.

How should I take Entresto?

Take Entresto exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

• You may take Entresto with or without food. Take the medicine at the same time each day.
• Sacubitril and valsartan doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.
• Your blood pressure will need to be checked often. Your kidney function may also need to be checked.
• Store Entresto in the original container at room temperature away from moisture and heat.
• Ask your doctor or pharmacist if you have any questions.

Entresto dosing information

Usual Adult Dose for Congestive Heart Failure:

• Initial dose: Sacubitril 49 mg-Valsartan 51 mg orally twice a day
• Maintenance dose: Sacubitril 97 mg-Valsartan 103 mg orally twice a day

Use

To reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic Class II to IV heart failure and reduced ejection fraction; usually administered in conjunction with other heart failure therapies or in place of an ACE inhibitor or other ARB.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What should I avoid while taking Entresto?

• Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
• Do not use potassium supplements or salt substitutes while you are taking Entresto, unless your doctor has told you to.
• Drinking alcohol can further lower your blood pressure and may increase certain side effects of Entresto.

Entresto side effects

Get emergency medical help if you have signs of an allergic reaction to Entresto: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. 

Also call your doctor at once if you have:

• a light-headed feeling, like you might pass out;
• extreme tiredness;
• high potassium - slow heart rate, weak pulse, muscle weakness, tingly feeling; or
• kidney problems - little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath.

Common Entresto side effects may include:

• dizziness; or
• cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. 

What other drugs will affect Entresto?

Tell your doctor about all your current medicines and any you start or stop using, especially:

• aliskiren;
• lithium;
• any other heart or blood pressure medicines;
• a diuretic;
• medicine or mineral supplements that contain potassium; or
• NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with sacubitril and valsartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are mentioned here, for more on the side effects and interactions, talk to your Doctor or Pharmacist.

References:

https://www.rxlist.com/entresto-side-effects-drug-center.htm

https://www.hey.nhs.uk/patient-leaflet/information-sacubitril-valsartan-entresto/

https://www.entresto.com/index.jsp

https://www.medicines.org.uk/emc/product/7751#gref

https://www.hse.ie/eng/about/who/cspd/ncps/medicines-management/prescribing-tips-and-tools/tips-and-tools-for-entresto.pdf

https://www.drugs.com/entresto.html

https://www.entresto.com/info/how-entresto-works.jsp?site=TP2

https://reference.medscape.com/drug/entresto-sacubitril-valsartan-1000010

https://www.entrestohcp.com