Midon Tablets are used to stop the fall in your blood pressure as a result of your sympathetic nervous system not working correctly. This should help to relieve the symptoms which you might be suffering such as dizziness, fainting, blurred vision and weakness when you sit or stand up.

Do not take the tablets if you:

• are allergic (hypersentitive) to midodrine hydrochloride or any of the other ingredients in the tablets
• have a tumour near the kidney, known as pheochromocytoma
• suffer from the eye disease narrow angle glaucoma
• have thyroid gland problems called thyrotoxicosis or hyperthyroidism i.e. overactive thyroid
• suffer from high blood pressure or a form of low blood pressure known as vasovagal hypotension
• some types of heart or blood vessel disease
• have inflammation of the kidneys, kidney disease, poor kidney function or if you are having 
problems passing urine
• damage to the retina in your eye as a result of diabetes (known as proliferative diabetic 
retinopathy)
• Men only: have an enlarged prostate that causes problems emptying your bladder.
• You should take your last dose of Midon Tablets at least four hours before bedtime. This is because Midon Tablets can cause high blood pressure if you are lying down for any period of time (for example, sleeping or sunbathing).

Talk to your doctor before taking these tablets if you have:

• any kidney problems
• had a stroke in the past or been told that you are at risk of a stroke
• any heart problems
• Your blood pressure will be monitored before starting, and during, treatment.
• If you experience any chest pain, palpitations, shortness of breath, headache, blurred vision, pulse slowing, increased dizziness or faintness during treatment, STOP taking the product and seek medical help immediately.

Taking other medicines

Please tell your doctor if you are taking, or have recently taken any other medicines, including medicines obtained without a prescription, but particularly if you are taking:

• high blood pressure medicines e.g. alpha blockers or beta blockers
• glycosides to increase the force of your heart beat e.g. digitalis
• tricyclic antidepressants for depression or monoamine oxidase inhibitors (MAOIs)
• amiodarone (used to control heart arrhythmias). Midon may increase the effect of this drug
• metoclopramide (used to stop you feeling and being sick). Midon may increase the effect of this drug phenothiazines and atypical antipsychotics for schizophrenia or psychosis
• antihistamines for allergies
• appetite suppressants
• nasal/ sinus congestion relievers, especially those purchased without a prescription
• thyroid hormones
• steroids (for example, fludrocortisone). In combination with Midon Tablets, steroids may increase the risk of eye problems or a high blood pressure whilst lying down.

Taking Midon Tablets with food and drink.

• You can take these tablets with or without food.

Pregnancy and breast-feeding

• Safe use during pregnancy and breastfeeding has not been established.
Tell your doctor if you are pregnant, think you may be pregnant or are planning to become pregnant, or if you are breast-feeding. Midon Tablets should not be taken by pregnant or breastfeeding women unless advised by a doctor.
• Ask your doctor or pharmacist for advice before taking any medicine during pregnancy, or if you are breast-feeding.

Driving and using machinery

• Midon Tablets may make you feel dizzy or light headed; if this happens to you, do not drive or use machinery and ask your doctor for advice.

How to take Midon

• Swallow the tablet whole with a drink of water
• You should take your last dose of Midon Tablets at least four hours before bedtime. This is because Midon Tablets can cause high blood pressure if you are lying down for any period of time (for example, sleeping or sunbathing).

Adults and the Elderly:

• The usual starting dose is 2.5mg (1 tablet of 2.5mg) taken 2-3 times a day. Your doctor may increase this dose each week until the best effect is seen. Most people do not need more than 30mg a day. You should take the tablets during the daytime, when you are upright, at intervals of 3-4 hours.

Children:

• These tablets should not be given to children.

Do not stop taking these tablets without asking your doctor first.

Side Effects

STOP taking Midon Tablets and seek medical help immediately if you have any of the following which may be signs of an allergic reaction:

• difficulty breathing or swallowing
• swelling of the face, lips, tongue or throat
• severe itching of the skin, with a red rash or raised bumps.

The following side-effects may occur:

• hairs standing on end
• pain on passing urine
• at daily doses of more than 30 mg, high blood pressure when lying down (this might cause 
headaches, blurred vision, a “pounding” heartbeat, chest pain or shortness of breath)
• nausea, vomiting, indigestion, sore mouth
• chills
• rash, itching (particularly of the scalp), flushing
• inability to pass urine
• ‘pins and needles’

Midon Tablets can cause high blood pressure whilst lying down, particularly if the last dose of the day is taken too close to bedtime. This might cause: headaches, blurred vision, a “pounding” heartbeat, chest pain or shortness of breath. If these occur when you lie down or go to bed, tell your doctor. This is very important as, rarely, strokes have occurred. Your doctor may adjust your dose of Midon Tablets, or recommend that you raise the head of your bed.

If you are using Midon Tablets in combination with other medicines that raise blood pressure, for example fludrocortisone, and you find that your eyes are hurting or you experience visual disturbances (blurred vision) or you have a headache, especially behind the eye you should tell your doctor.

References:
https://www.medicines.ie/medicines/midon-tablets-2-5mg-32861/patient-info
https://www.hpra.ie/img/uploaded/swedocuments/Licence_PA2229-008-001_18112019170115.pdf 
https://www.sdrugs.com/?c=drug&s=midon&ingredient=midodrine%20hydrochloride